Human Growth Hormone: Research and Clinical Practice

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Roy G. Smith, Michael O. Thorner
Springer Science & Business Media, Jan 28, 2000 - Medical - 348 pages
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In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.
 

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Contents

Contributors
3
FEIGHNER PHD Department of Biochemistry and Physiology Merck Co
13
Research
15
The Design of Peptidomimetic Growth Hormone
45
Molecular Characterization of Growth Hormone
69
Central Actions of Peptide and Nonpeptide
85
Pharmacology of Growth HormoneReleasing Hormone
97
Somatostatin Receptor Subtypes and Regulation
109
Relevance to Pediatrics
191
The Rationale
221
Growth Hormone and Osteoporosis
233
Growth Hormone and Syndrome X
247
Interactions Between Growth Hormone Secretion and Sleep
261
Growth Hormone in AIDS
285
Clinical and Physiological Studies
297
Clinical Use of Growth Hormone Secretagogues
315

Mathematical Modeling of the GH Release Axis
119
The Central Nervous System as a Direct Target
145
11
169

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