Human Growth Hormone: Research and Clinical PracticeRoy G. Smith, Michael O. Thorner In a state-of-the-art synthesis of basic science and clinical practice, Roy Smith and a distinguished panel of researchers and clinicians review GH regulation and its action at the molecular level, and describe the basis for GH deficiency and the use of GH as therapy in a variety of clinical situations. The clinical presentation moves beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, GHRH in clinical studies. Timely and innovative, Human Growth Hormone: Research and Clinical Practice will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease. |
Contents
3 | |
13 | |
Research | 15 |
The Design of Peptidomimetic Growth Hormone | 45 |
Molecular Characterization of Growth Hormone | 69 |
Central Actions of Peptide and Nonpeptide | 85 |
Pharmacology of Growth HormoneReleasing Hormone | 97 |
Somatostatin Receptor Subtypes and Regulation | 109 |
Relevance to Pediatrics | 191 |
The Rationale | 221 |
Growth Hormone and Osteoporosis | 233 |
Growth Hormone and Syndrome X | 247 |
Interactions Between Growth Hormone Secretion and Sleep | 261 |
Growth Hormone in AIDS | 285 |
Clinical and Physiological Studies | 297 |
Clinical Use of Growth Hormone Secretagogues | 315 |
Other editions - View all
Human Growth Hormone: Research and Clinical Practice Roy G. Smith,Michael O. Thorner No preview available - 2000 |
Human Growth Hormone: Research and Clinical Practice Roy G. Smith,Michael O. Thorner No preview available - 2000 |
Common terms and phrases
activity aequorin agonist amino acid analogs antagonist arcuate nucleus Bercu binding bone density Bowers CY Clin Endocrinol Metab clinical cloned cortisol decreased demonstrated desensitization domain dose effects of GH Endocrinology endogenous extracellular function gene GH administration GH deficiency GH pulse GH receptor GH release GH replacement GH response GH secretagogue GH secretion GH secretory GH treatment GHRH GHRP GHS-R growth hormone deficiency growth hormone GH growth hormone receptor growth hormone secretagogues growth hormone secretion growth hormone treatment growth hormone-releasing factor growth hormone-releasing hormone hGHR human growth hormone hypothalamic increased infusion inhibition injection insulin insulin-like growth factor ligand metabolism molecular mRNA mutations neurons ng/mL normal obesity patients peptide physiological pituitary cell plasma potent protein recombinant human regulation residues response to GHRH rhGH Robinson ICAF serum Smith RG somatostatin somatotrophs SRIF receptor sstr2 stimulation studies SW sleep syndrome vitro µg/kg µg/L