Molecular Basis of AgingUsing a new, integrative approach, Molecular Basis of Aging describes the aging phenomenon within mammalian organisms from the perspective of changes in information storage and coordination between hierarchical orders of structure. This unique approach provides the reader with a thorough insight into the evolution of molecular, cellular, tissue, and organ systems and processes in mammals. This informative volume contains up-to-date reviews of: |
Contents
A MacieiraCoelho | 22 |
Genome Reorganization During Senescence | 29 |
Chapter 2 | 71 |
Chapter 3 | 137 |
Chapter 4 | 183 |
Chapter 5 | 219 |
Chapter 6 | 237 |
Chapter 7 | 269 |
Chapter 11 | 353 |
Chapter 12 | 389 |
Chapter 13 | 421 |
Chapter 14 | 437 |
Chapter 15 | 459 |
Chapter 16 | 493 |
Chapter 17 | 511 |
Chapter 18 | 527 |
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Common terms and phrases
Acad activity age-dependent age-related changes aged rats Ageing Dev aging process alterations Alzheimer's disease amino acid amyloid amyloidosis animals antibodies axonal binding Biochem Biol biological Biophys calcium cellular Chem chromatin chromosomal aberrations collagen complex correlation cross-linking cytoplasmic cytoskeleton decrease diploid DMcarbonyls DNA damage DNA methylation DNA repair DNA synthesis elastin enzymes erythrocytes factors fibroblasts fibronectin Figure filaments free radical function gene expression genetic genome Gerontol glycation human fibroblasts increase induced interactions isoforms lesions levels lipid lymphocytes Macieira-Coelho mammalian matrix Mech mechanisms membrane metabolism methylation mice mitochondrial modifications molecular molecules mouse mRNA mtDNA mutations Natl neurons normal nuclear nucleus old rats organism oxidative peptide phagocytosis phosphorylation poly(A postmitotic cells Proc proliferation protein kinase protein synthesis rat liver receptors replication ribosomal role senescent sequence single-strand breaks somatic span specific structure studies telomeres tion tissues transcription translocation transport ubiquitin vitro vivo